Make it easy!
About us
Our group’s research interests center on the discovery of new reactions and the application of them to challenging problems in organic synthesis.
Publications 2025
Base-controlled regioselectivity via distinct mechanisms during C–H thionation of azinium salts with elemental sulfur
Synthesis of 2-Aminobenzo[b]thiophenes via an Intramolecular Dehydrogenative C–S Bond Formation Effected by Iodine(III) Reagents
Synthesis, 2025, 57, 1034-1042
Invited Article
4-Aryl-1,2,3-thiadiazoles as alkynyl thiolate surrogates in the reactions with diaryliodonium salts: a transition-metal-free route to alkynyl aryl sulfides
Publications 2024
Visible Light instead of Transition Metal: Electron Donor Acceptor Complex Enabled Cross-Coupling of Aryl Halides with Active Methylene Compounds
Hot Topic: C-C Coupling from ChemCatChem
Transition Metal and Photocatalyst Free Arylation via Photoexcitable Electron Donor Acceptor Complexes: Mediation and Catalysis
Recent Progress in Functionalization of the Pyridine Ring through C–S Bond Formation under Transition Metal Catalyst Free Conditions
Hot Topic: C-H Activation from Asian J. Org. Chem.
N-Aryl-DABCO Salts as an Unprecedented Sensing Platform for the Detection of Thiols and Selenols
(Indol-3-yl)(DMIX)Iodonium Salts: Novel Electrophilic Indole Reagents
Arylation of Diethyl Acetamidomalonate with Diaryliodonium Salts En Route to α-Arylglycines
Publications 2023
Synthesis of Quinoline-2-thiones by Selective Deoxygenative C–H/C–S Functionalization of Quinoline N-Oxides with Thiourea
Highlighted by OrgChemPort
Reaction of Diaryliodonium Salts with Potassium Alkyl Xanthates as an Entry Point to Accessing Organosulfur Compounds
Highlighted by OrgChemPort
Electron Donor-Acceptor Complex Initiated Photochemical Phosphorus Arylation with Diaryliodonium Salts toward the Synthesis of Phosphine Oxides
Publications 2022
Catalyst-Free Visible Light Mediated Synthesis of Unsymmetrical Tertiary Arylphosphines
Transition metal-free cross-coupling reactions to form carbon–heteroatom bonds
Visible-Light-Driven Thioesterification of Aryl Halides with Potassium Thiocarboxylates: Transition-Metal Catalyst-Free Incorporation of Sulfur Functionalities into an Aromatic Ring
Publications 2017-2021
From Pyridine-N-oxides to 2-Functionalized Pyridines through Pyridyl Phosphonium Salts: An Umpolung Strategy
Generation of aryl radicals by redox processes. Recent progress in the arylation methodology
Reaction of Pyridine-N-Oxides with Tertiary sp2-N-Nucleophiles: An Efficient Synthesis of Precursors for N-(Pyrid-2-yl)-Substituted N-Heterocyclic Carbenes
N-Substituted pyridinium salts as reagents for radical functionalization using visible light
The versatility of DABCO: synthetic applications of its basic, nucleophilic, and catalytic properties
Catalyst-Free Arylation of Tertiary Phosphines with Diaryliodonium Salts Enabled by Visible Light
Fluorescent probes on the basis of coumarin derivatives for determining biogenic thiols and thiophenols
N-Arylation of DABCO with Diaryliodonium Salts: General Synthesis of N-Aryl-DABCO Salts as Precursors for 1,4-Disubstituted Piperazines
Arynes, diaryliodonium salts and azine N-oxides in transition metal-free electrophilic N-arylation
New methodology for one-pot С–H functionalization of pyridines without the use of transition metal catalysts
Synthesis of Indoles via Electron-Catalyzed Intramolecular C–N Bond Formation
Highlighted by OPR&D
Highlighted by OrgChemPortTop 20 viewed articles OrgLett
December 2018 – January 2019
1,4-Diazabicyclo[2.2.2]octane in the synthesis of piperazine derivatives
Quaternary N-(2-Pyridyl)-DABCO Salts: One-Pot in Situ Formation from Pyridine-N-oxides and Reactions with Nucleophiles: A Mild and Selective Route to Substituted N-(2-Pyridyl)-N′-ethylpiperazines
News
Посветил — и готово
Новый, дешевый и безопасный способ получения органических катализаторов
Российские ученые разработали простой, дешевый и эффективный метод синтеза арилфосфинов — важного компонента многих органических катализаторов на основе переходных металлов. Оказалось, что для их получения достаточно осветить исходные соединения диодной лампой. При традиционных способах требуется долгая и сложная очистка с применением довольно токсичных катализаторов и реагентов. Предложенное решение найдет применение в фармацевтической промышленности и производстве органических материалов для электроники. Исследование поддержано грантом Российского научного фонда.
Использованы материалы с сайта https://www.kommersant.ru
Разработана методика экологичного синтеза жаропонижающих препаратов
Российские химики разработали подход, позволяющий получать азот- и серосодержащие производные органического вещества индола, которые широко применяются при синтезе различных жаропонижающих и обезболивающих средств, а также искусственных гормонов и удобрений.
Использованы материалы с сайта https://tass.ru
Congratulations to Polina on her first article in our group!
The use of readily available 1,2,3-thiadiazoles as surrogates of transient alkynyl thiolate anions and diaryliodonium salts as arylating agents allowed for the first time the synthesis of alkynyl aryl sulfides via C(sp2)–S bond formation under transition metal-free conditions.
Каrchava's Team
Alexander Karchava
PhD in Chemistry, Docent
PhD, Moscow State University, 1996
Dmitry Bugaenko
PhD in Chemistry, Docent
PhD, Moscow State University, 2021
Nikita Andreevsky
B.S. 2025
Moscow State University
Contacts
Our youth team is interested in developing collaborations and working on joint projects. We welcome suggestions and development.
119991, Moscow, Leninskye Gory, 1/3, office 406
karchava@org.chem.msu.rubugaenko@org.chem.msu.ru
Moscow State University
Chemistry department
Chemistry department
Funding, partners, collaborations
Moscow State University
Chemistry department
Russian Science Foundation
Russian Foundation for Basic Research
Innovation Support Fund
State Scientific Institution "Institute of Physical and Organic Chemistry of the National Academy of Sciences of Belarus"
N. D. Zelinsky Instituteof Organic Chemistry Russian Academy of Sciences
